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Uninstalling it will definitely stop it from launching on boot-up, yes - though you won't be able to play Valorant without it. All the program does is prevent you from launching cheat-creation software, or other recognized cheat software.

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Technically it does slow your system down a bit, which will be noticeable on lower-end systems... The program is designed to block you from cheats and cheat-creation software, so most people won't even notice it running, but you can turn it off to save a few frames in other games.

Does Riot Vanguard slow down your PC? - Players' POV - Buff Community

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